Kleenex is scrapping "Mansize" branding from its tissue boxes after 60 years on the shelves as consumers called it out for being sexist.
The company said the tissues would now be called "Extra Large".
One customer questioned the firm after her four-year-old son asked if "girls, boys and mummies" can use them.
Kleenex told shoppers to "keep an eye out" for the new branding, saying some of its new larger boxes are already on sale.
Kleenex For Men first launched in 1956, offering an alternative to large cotton handkerchiefs that were still popular at the time, and claiming to "stay strong when wet".
Kleenex thanked customers for their concern and confirmed the new "Extra Large" labelling.
The BBC has approached Kleenex for comment, but the company has yet to respond.
However, in a statement given to the Daily Telegraph, a spokesman for its parent company, Kimberly-Clark, said the firm was registering "a consistent increase of complaints on gender concern".
He added: "Kimberly-Clark in no way suggests that being both soft and strong is an exclusively masculine trait, nor do we believe that the Mansize branding suggests or endorses gender inequality.
"Nevertheless, as we remain committed to developing the best possible products for our consumers and take any feedback extremely seriously, we decided to renovate our current product and update the product subbrand as Kleenex Extra Large."
The Advertising Standards Authority - which regulates adverts in the UK - told the BBC it had not received any complaints about the product, but it was carrying out "a significant amount of work around gender stereotypes in ads".
Plans include setting new standards on adverts that feature stereotypical gender roles or characteristics, and cracking down on those which mock people for not conforming to stereotypes.